Earlier this year, Nature published a paper on Late-Onset Alzheimer’s Disease (LOAD) from researchers at the MCIN. The paper describes the discovery that, contrary to previous understanding, the first physiological sign of Alzheimer’s disease is a decrease in blood flow in the brain.
LOAD is a complex disease as it is not caused by one neurological mechanism, but is a result of several associated mechanisms in the brain. LOAD is a common cause of dementia in humans, and an understanding of the various mechanisms and their interactions is important to developing treatments.
Further reading can be found here:
McGill Newsroom – “Big Data” study discovers earliest sign of Alzheimer’s
McGill Newsroom – Decoding Connectivity
Alzforum – LOAD of Data Place Vascular Malfunction as Earliest Event in Alzheimer’s
ICI Radio Canada – Le premier signe précurseur de l’alzheimer découvert grâce aux métadonnées (Français)