Neuroimaging Methods

Acquisition Protocols

Recent advances in MRI scanner design provide for new sophisticated scan  protocols for high resolution multi-modal data.  Here we provide a protocol  developed for a Brain Canada project acquiring MRI data on the MNI’s new Siemens Prisma 3T from individuals with interesting genetic alterations.


Sampling & Statistics

Research on optimization of statistical criteria in neuroimaging began early and through close collaboration with the late professor Keith Worsley, who introduced the Random Field Theory in neuroimaging–a pioneering approach for addressing the problem of false positives and multiple comparisons.


In the last decade, an alternative to “Talairach space” has been widely adopted in the brain mapping field, the so-called “MNI space”. This latter space has evolved through various phases.

Brain Connectivity

To characterize the underlying architectures of brain networks is central to current neuroimaging research. Mathematical modeling provides generalizable definitions for the structural and functional organization of the human brain.


Morphometric Analysis

Population studies in neurodegenerative disease and neurodevelopment are supported by ongoing development of feature-specific and sensitive methods that help detect statistical deviations of the anatomical features from the “normal” brain.